Technology Portfolium

The Industrial Property Unit of ICIQ aims at advising ICIQ researchers in IP protection; identifying inventions to be protected; managing the patent application and patent granting processes; managing valorization activities of patent applications and, ultimately, and as the main objective, transfer ICIQ’s IP to industry or to spin-off companies.
 
ICIQ’S IN-HOUSE DEVELOPED TECHNOLOGIES

 
At ICIQ, we consider that patents are highly efficient, safe and solid tools to provide protection from competitors. This is why we file patents for our in-house developed-technologies: to give our co-development projects with industry a strong starting IP position.  As a research centre our goal is always to co-develop our technology adapting it to the industrial partner’s specific needs and ultimately transfer the technology to this company, with a flexible licensing strategy adapted to each case.

 

This site is designed to serve as a showcase of the technologies developed within the Institute, thus making the contact between ICIQ and possible licensees and/or partners easier.
 

Please contact us for more information.

Technology Portfolio

 

ICIQ

Hypervalent iodine reagents for amination reactions.
New reagents based on hypervalent iodine compounds that readily react with a wide substrate family to form the corresponding aminated products. Particularly, alkenes readily react to give the corresponding 1,2-diamine and enolizable ketones lead to the formation of the corresponding alpha-aminoketo derivative. Enantioselective 1,2-diamination of some alkenes was also developped.

ICIQ scientists have discovered a novel, highly sought after reaction: direct cupration of fluoroform (other names: trifluoromethane; HFC-23; R-23). Our exceedingly simple process employs only cheap reagents and is advantageously run at room temperature to produce CuCF3 reagents that are useful in trifluoromethylation reactions.  Partnership is offered for process optimization and adaptation to specific needs.

A process for the preparation of (-)-englerin A, and intermediates thereof.
A process for the total synthesis of enantiomerically pure (-)-Englerin A from readily available cheap raw materials and using a key catalytic cyclization step has been developed. This procedure allows for the preparation of analogs of (-)-Englerin A, a natural product known for its high activity against renal cancer.

Process for the catalytic intermolecular 1,2-diamination of alkenes.
Process for the intermolecular palladium-catalyzed diamination of unactivated alkenes in the presence of an oxidant. The offered process involves the use of commercially available saccharin and sulfonylimides as nitrogen sources, that insert regio- and chemoselectively into the double bond. Each amino group can be independently modified in following steps.

cLab: a web portal to access, use and manage computational resources.
The Computational Laboratory Web Manager (cLab) is a web portal that permits the access and the management of a computational laboratory, which is a high performance hypercomputation center based on heterogeneous clusters of computers and used by multiple users simultaneously for the execution of computational jobs.

Purification of fullerenes by selective encapsulation mediated solid-liquid extraction.
A concave compound self assembles thanks to reversible and controlable hydrogen bonding to form a dynamic capsule able to selectively extract fullerene derivatives of given size and shape.

New Bisdiglycolamides as extractants of lanthanides [Ln(III)] and actinides [An(III)] from high-level aqueous wastes.
Highly efficient and resistant extractant of lanthanides and actinides from high-level aqueous nuclear wastes resulting from the PUREX process to be used in the SANEX process (extraction of lanthanides and actinides from nuclear wastes) are offered.

Universidad de Valladolid

A new type of stannylated polymers based on the robust vinylic polynorbonene backbone are suitable reagents in the Stille coupling or other organotin‐based reactions. The tin polymers are recyclable and can be immobilized and used in a batch procedure. The products are obtained following a very simple workup and have very low tin contamination.
 
Functionalized vinylic polynorbornenes can be obtained by copolymerization of norbornene and haloakyl substituted norbornenes. Substitution of the halogen by other functional groups of interest is possible. Thus, these new polymers are good precursors to support catalysts or reagents on the vinylic polynorbornene skeleton, which is thermally stable, and robust under most reaction conditions.

Procedure for the enantioselective addition of organozincs to aryl trifluoromethylketones, and compounds therefrom.
Chiral alcohols bearing a CF3 substituent are the head of series of molecules actively investigated against Tipe II diabetes and obesity. These can be prepared enantioselectively in high enantiomeric excess by a catalytic procedure that allows the addition of ZnMe2 and ZnEt2 to different Ar‐C(O)‐CF3 substrates in a single step. Our procedure can replace advantageously the actual multistep racemic procedure. Moreover, it allows for the synthesis of unreported chiral alcohols ArEt(CF3)C‐OH.