Boron trifluoride-induced reactions of phenylglycidyl ethers: A convenient synthesis of enantiopure, stereodefined fluorohydrins
G. Islas-González, C. Puigjaner, A. Vidal-Ferran, A. Moyano, A. Rieraa, M. A. Pericàs
Tetrahedron Lett. 2004, 45, 6337-6341
Abstract: Ring-opening hydrofluorination of enantiomerically pure (2S,3S)-3-arylglycidyl ethers (aryl = phenyl, 4-trifluoromethylphenyl) by boron trifluoride–diethyl ether under mild conditions provides ß-fluoro alcohols in good yield in a stereospecific manner with complete regiocontrol.