Divergent titanium-mediated allylations with modulation by nickel or palladium
A. G. Campaña, B. Bazdi, N. Fuentes, R. Robles, J. M. Cuerva, J. E. Oltra, S. Porcel, A. M. Echavarren
Angew. Chem. Int. Ed. 2008, 47, 7515-7519
Abstract: Palladium and nickel are used in conjunction with titanocene(III) complexes to perform selective allylations of carbonyl compounds and alkenes, respectively. Pd/Ti-catalyzed allylation of ketones proceeds diastereoselectively under mild conditions, whereas Ni/Ti-promoted cyclizations provide polyalkyl-substituted carbo- and heterocycles with excellent control over regio- and stereoselectivity.