A three-component tandem reductive Aldol reaction catalyzed by N-heterocyclic carbene-copper complexes
A. Welle, S. Díez-González, S. P. Nolan, O. Riant
Org. Lett. 2006, 8, 6059-6062
Abstract: An efficient catalytic system for the three-component coupling of electrophilic alkenes, aldehydes, and silane was optimized with a new family of copper N-heterocyclic carbene complexes. These catalysts do not require activation and show high activity (TOF > 15 000 h-1) as well as some anti diastereoselectivity.