Prins cyclizations in Au-catalyzed reactions of enynes
E. Jiménez-Núñez, C. K. Claverie, C. Nieto-Oberhuber, A. M. Echavarren
Angew. Chem. Int. Ed. 2006, 45, 5452-5455
Abstract: AuI-catalyzed cyclizations of functionalized enynes lead to the ready assembly of tricyclic carbon skeletons that are present in a number of naturally occurring compounds. An alkenyl gold intermediate is formed in the cyclization of the enynes and can be trapped in 5-exo-dig or 6-endo-dig Prins reactions to form an additional CC bond. Z=C(CO2Me)2, NTs; R=H, Me, iPr