Synthesis of heavily substituted 1,2-amino alcohols in enantiomerically pure form
N. García-Delgado, K. Subba Reddy, L. Solà, A. Riera, M. A. Pericàs, X. Verdaguer
J. Org. Chem. 2005, 70, 7426-7428
Abstract: A simple and convenient methodology for the preparation of optically pure 2-amino-2-aryl-1,1-diphenylethanols is presented. Allylamine was found to produce the ring-opening of triaryloxiranes in a regioselective and a stereospecific fashion. Removal of the allyl protecting group provided the free 1,2-amino alcohols in enantiomerically pure form.