Pd-catalyzed intramolecular acylation of aryl bromides via C-H functionalization: A highly efficient synthesis of benzocyclobutenones
P. Álvarez-Bercedo, A. Flores-Gaspar, A. Correa, R. Martin
J. Am. Chem. Soc. 2010, 132, 466-467
Abstract: A new catalyst system for the intramolecular acylation of aldehydes with aryl bromides via C−H functionalization is described. The transformation is distinguished by a remarkable functional group tolerance and hence allows for the synthesis of a wide variety of highly functionalized benzocyclobutenones with a diverse set of substitution patterns from simple and easily accessible precursors.