Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
J. Rolland, X. C. Cambeiro, C. Rodríguez-Escrich, Miquel A. Pericàs
Beilstein J. Org. Chem. 2009, 5, 56
Abstract: A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.